Tell clients that hydrocodone bitartrate and acetaminophen tablets could bring about a uncommon but probably lifestyle-threatening situation ensuing from concomitant administration of serotonergic medications.
Inform woman patients of reproductive likely that extended utilization of hydrocodone bitartrate and acetaminophen tablets in the course of pregnancy may lead to neonatal opioid withdrawal syndrome, which may be lifestyle-threatening if not identified and addressed [see WARNINGS, Safeguards; Pregnancy].
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Inside a 2015 examine comparing the prescription drugs, scientists observed which they equally worked Similarly effectively for brief-term discomfort administration. An older 2005 research confirmed they perform Similarly well in managing acute ache a result of fractures.
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Abide by people carefully for respiratory depression, Primarily inside the first 24-72 several hours of initiating therapy and subsequent dosage will increase with hydrocodone bitartrate and acetaminophen tablets and modify the dosage appropriately [see WARNINGS].
The specific mechanism of the analgesic motion is unfamiliar. Even so, certain CNS opioid receptors for endogenous compounds with opioid-like activity are actually determined through the entire Mind and spinal cord and so are believed to Participate in a role during the analgesic results of the drug.
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Quickly halting this medication may well bring about withdrawal, particularly when you have got made use of it for a long time or in high doses. To prevent withdrawal, your doctor may lessen your dose slowly but surely.
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Warning Hydrocodone/acetaminophen features a threat for abuse and habit, which can cause overdose and Demise. Hydrocodone/acetaminophen may induce severe, probably fatal, breathing problems.
Tell sufferers and caregivers that perhaps deadly additive outcomes may possibly come about if hydrocodone bitartrate and acetaminophen tablets are made use of with benzodiazepines and other CNS depressants, such as alcohol, instead of to employ these concomitantly Except supervised by a Health care company [see WARNINGS, DRUG INTERACTIONS].
For those who skip a dose, just take your common dose at another usual time if required. Usually do not just take in excess of your prescribed dose.